Verified
Pfizer
Scaling- Pharma
- ~75,000 employees
- 98% of eligible staff took AI course
- In-house AI backbone
- 1,200+ GPUs planned
- Fortune AIQ 75 #48
Pfizer deploys AI through an enterprise backbone run by its technology team, while each division owns its AI strategy, models and spending. Named tools include Vox, which gave scientists Anthropic's Claude on Amazon Bedrock, and Charlie for marketing content; Boltz and Chai Discovery supply drug discovery models. Pfizer made scaling AI a 2026 priority and says 98% of eligible employees took its first AI course. Albert Bourla calls AI a significant contributor to $5.6 billion of cost cuts, without separating its share.
pfizer.comTheir approach to AI
- The platform
- Pfizer's technology team builds and manages an enterprise AI backbone while each division owns its AI strategy, model use and investment (Fortune, Sep 2026); named tools include Vox for scientists and Charlie for marketing content.
- The models
- Pfizer's Vox gave scientists Anthropic's Claude 2.1 through Amazon Bedrock (undated AWS case study), Charlie generated marketing content with a custom version of ChatGPT built with Publicis Groupe (Feb 2024), and Boltz and Chai Discovery supply drug discovery models (2026).
- The reach
- Pfizer says 98% of eligible employees have taken the first course of its AI certification program, which Fortune reported in Sep 2026 as 98% of the workforce; Pfizer employed about 75,000 people at the end of 2025 and has not published how many use its AI tools each week.
- The catch
- Pfizer has not separated AI's share of its cost savings from simplification, and AI leadership changed hands in 2026: Jeremy Forman became Chief AI, Data and Analytics Officer in Feb 2026, Lidia Fonseca left the Chief Digital and Technology Officer role in Apr 2026, and Dennis Hancock was promoted to CIO by Jul 2026.
Snapshot
- Employees
- ~75,000
- Dec 31, 2025 (2025 Form 10-K)
- Technology budget
- Not disclosed
- R&D spending about $11B in 2026 (Feb 2026 earnings call)
- Who owns AI
- Dennis Hancock, CIO and EVP
- Leads technology, digital and AI strategy (Jul 2026); Jeremy Forman, Chief AI, Data and Analytics Officer since Feb 2026; Lidia Fonseca, CDTO 2019 to Apr 2026
- Platform
- Enterprise AI backbone
- Run by the technology team; Vox for scientists, Charlie for marketing
- Models
- Anthropic, OpenAI, partner models
- Claude via Amazon Bedrock (undated AWS case study), a custom ChatGPT (Feb 2024); Boltz and Chai (2026)
- Reach
- 98% took the first AI course
- Eligible employees, per Pfizer; active users not published
- Use cases
- R&D to enabling functions
- No count published; a return credited to Golden Batch in manufacturing
Key findings
Pfizer says 98% of eligible employees have taken the first course of its AI certification program, and Fortune reported in Sep 2026 that each Pfizer division owns its AI strategy, model use and investment while the technology team builds and manages the enterprise AI backbone.
Albert Bourla made scaling AI one of Pfizer's four strategic priorities for 2026 and said on Feb 3, 2026 that Pfizer is expanding to more than 1,200 GPUs over two years, largely for AI in R&D.
Albert Bourla said on Jan 12, 2026 that AI was a significant contributor to the $5.6 billion of cost Pfizer took out, and on Feb 3, 2026 called AI the main lever alongside simplification; Pfizer has not separated AI's share, and in Aug 2026 Pfizer added $1.0 billion of savings for 2027 to 2029, citing technology and simplification.
Pfizer's AI leadership turned over in 2026: Jeremy Forman was promoted to Chief AI, Data and Analytics Officer in Feb 2026, Lidia Fonseca left the Chief Digital and Technology Officer role in Apr 2026 to become Senior Advisor to the CEO (Medtronic proxy, Aug 2026), and CDO Magazine reported on Jul 6, 2026 that Pfizer promoted Dennis Hancock, at Pfizer since 1995, to CIO and EVP over enterprise technology, digital and AI strategy.
Pfizer sources drug discovery models from partners: Boltz agreed in Jan 2026 to refine its open-source models on Pfizer's historical data into exclusive Pfizer models, and Pfizer licensed Chai Discovery's Chai-3 antibody design model in Jun 2026.
Where Pfizer sits
- Stage
- Scaling
Pfizer sits at Scaling: AI runs in production across drug discovery, clinical development, manufacturing, supply planning, field sales, marketing and enabling functions, 98% of eligible employees have taken the first course of Pfizer's AI certification program, scaling AI is one of Pfizer's four 2026 priorities, and Albert Bourla reports AI results on earnings calls. CIO Dennis Hancock owns enterprise AI strategy, and Jeremy Forman has been Chief AI, Data and Analytics Officer since Feb 2026. Pfizer falls short of Embedded on two tests: Pfizer has published no weekly usage figure or count of AI use cases, and has not separated AI's share of its cost savings from simplification.
How the stages are defined - Ownership
- CIO and EVP Dennis Hancock; Chief AI, Data and Analytics Officer Jeremy Forman (Feb 2026)
- Platform
- Hybrid: Enterprise AI backbone built in-house; Vox, Charlie; partner models
- Models
- Anthropic Claude via Bedrock, custom ChatGPT, Boltz and Chai models
- Hosting
- AWS (Bedrock, SageMaker) for Vox and lab tools; 80% of infrastructure cloud-based by 2023; GPU and Charlie hosting not disclosed
- Reach
- 98% of eligible staff took the first AI course
How they deploy
Scaling AI is a 2026 priority
Pfizer lists scaling AI across the business as one of its four strategic priorities for 2026 in its 2025 Form 10-K, beside maximizing key transactions, R&D milestones and post-2028 growth. Albert Bourla said on Feb 3, 2026 that Pfizer had laid the groundwork with AI-ready data, agentic workflows and compute capacity, and on May 5, 2026 said the coming years are the time to carry out the AI transformation of Pfizer rather than pursue a large merger.
Divisions own use cases, technology runs the backbone
Fortune reported in Sep 2026 that every Pfizer division owns its AI strategy, model use and investments, while Pfizer's technology team develops and manages the enterprise AI backbone across those use cases. Chris Boshoff said in Feb 2026 that Pfizer R&D is recruiting AI engineers into each function, from discovery and regulatory to pharmacovigilance and clinical trial execution, to measure productivity, speed and cost. Alexandre de Germay said in Sep 2026 that Pfizer's international commercial division sets its own AI priorities, tests tools and then rolls them out across its markets.
Training alongside tools
Pfizer says 98% of eligible employees have taken the first course of an AI certification program tailored to every role and function, which Fortune reported in Sep 2026 as 98% of the workforce. Albert Bourla said in May 2026 that Pfizer pairs frontier AI tools tailored to each function and role with continuously updated training, and told Fortune in Jan 2026 that companies will win with AI by transforming their own organizations, not by choosing the right vendor.
Partners for science models
Pfizer works with outside AI developers for drug discovery models: XtalPi on molecular modeling since May 2018 and on quantum computing, PostEra on AI drug discovery, Boltz from Jan 2026 to refine open-source biomolecular foundation models into exclusive models trained on Pfizer's historical data, and Chai Discovery from Jun 2026 for its Chai-3 antibody design model. Pfizer keeps full ownership of compounds discovered with the Boltz models.
AI as a cost lever
Pfizer ties part of its multiyear cost realignment program to AI. In Apr 2025 Pfizer added about $1.2 billion of targeted savings, mainly in selling, informational and administrative costs, driven in large part by digital enablement including automation and AI along with simpler processes. In Aug 2026 Pfizer added another $1.0 billion for 2027 to 2029 from technology and simplification across commercial, R&D and enabling functions, which Albert Bourla described as powered in part by rapid advances in technology.
- Deployment model
- Pfizer runs AI as a shared backbone with delivery in the businesses. Pfizer's technology organization, Pfizer Digital, builds and manages the enterprise AI backbone, while each division sets its own AI strategy, model use and spending (Fortune, Sep 2026). Chief Digital and Technology Officer Lidia Fonseca led the organization until Apr 2026, and CIO and EVP Dennis Hancock now leads Pfizer's enterprise technology, digital and AI strategy (CDO Magazine, Jul 2026). Jeremy Forman, promoted to Chief AI, Data and Analytics Officer in Feb 2026, is charged with integrating AI and data across the enterprise (CDO Magazine, Feb 2026). Pfizer also has an AI Council, which Chief AI and Analytics Officer Berta Rodriguez-Hervas joined as co-chair in Aug 2024. R&D embeds AI engineers in each function, and Pfizer's enabling functions use AI that its large technology vendors build into their platforms, Pfizer's CFO said in Feb 2026.
- Model providers
- Pfizer uses several model providers and lets divisions choose their model use (Fortune, Sep 2026). Pfizer built Vox on AWS with large language models from Amazon SageMaker and Amazon Bedrock (AWS re:Invent, Nov 2023), and an undated AWS case study says Vox search uses Anthropic's Claude 2.1 through Bedrock. Charlie, the marketing content platform Pfizer built with Publicis Groupe on its Marcel platform, generates content with a custom version of ChatGPT (Digiday, Feb 2024). For science, Pfizer licenses Chai Discovery's Chai-3 model (Jun 2026), has Boltz refine its open-source Boltz-2 and BoltzGen models on Pfizer data (Jan 2026), and works with XtalPi and PostEra. Pfizer's 2025 Form 10-K lists reliance on a small number of AI models or service providers as a risk.
- Data and infrastructure
- Pfizer runs most of its infrastructure in the cloud: AWS's page on Lidia Fonseca's re:Invent keynote (Nov 2023) says Pfizer went from about 10% to 80% cloud-based and built a Scientific Data Cloud with AWS that gathers data from hundreds of lab instruments. Pfizer and Amazon Web Services launched the Pfizer-Amazon Collaboration Team (PACT) in 2021 in Pfizer's Pharmaceutical Sciences Small Molecule group, applying AWS analytics, machine learning, compute and storage to lab, clinical manufacturing and clinical supply work; five of PACT's first 14 prototypes moved into production. Albert Bourla said on Feb 3, 2026 that Pfizer is expanding to more than 1,200 GPUs over two years, largely for R&D, without saying where they run. Bourla said in May 2026 that Pfizer holds a large repository of small and large molecule, translational and clinical data for AI to mine, and the Boltz collaboration refines models on that historical data while Pfizer keeps ownership of any compounds.
Platforms and internal tools
Enterprise AI backbone
Pfizer's technology team builds and manages an enterprise AI backbone that each division draws on for its own AI strategy, models and investments (Fortune, Sep 2026). Albert Bourla said in Feb 2026 that the foundation includes AI-ready data, agentic workflows and compute, with more than 1,200 GPUs planned over two years.
VoxBy Nov 2023
Vox is Pfizer's internal generative AI platform, built on AWS with large language models from Amazon SageMaker and Amazon Bedrock, which AWS's page on Lidia Fonseca's re:Invent keynote (Nov 2023) describes as speeding research and predicting product yield. Scientists use Vox to search documents by voice command and chatbot in natural language; PACT's first use case targeted data discovery for 1,500 Pharmaceutical Sciences Small Molecule scientists, for whom one drug can generate about 20,000 documents, according to an undated AWS case study.
- Users
- 1,500 scientists targeted in the first use case (AWS case study)
- Models
- SageMaker and Bedrock models, including Anthropic Claude 2.1; Amazon Kendra for search
Charlie2023 to 2024
Charlie, named after Pfizer's co-founder, is Pfizer's generative AI platform for marketing content and the marketing workbench, built with Publicis Groupe on its Marcel platform. Charlie drafts digital media, emails and sales presentations for physicians, labels assets red, yellow or green for medical, legal and regulatory review, checks answers against approved Pfizer content, and connects to Adobe Workfront, Adobe Experience Manager and Slack (Digiday, Feb 2024).
- Users
- Hundreds in central marketing and thousands across brands, plus agencies Publicis Groupe and IPG (Feb 2024)
- Models
- Custom version of ChatGPT
PACT manufacturing analyticsPACT from 2021
A PACT prototype built on Amazon SageMaker and Amazon Lookout for Equipment detects anomalies in Pfizer's Portable Continuous Miniature and Modular (PCMM) line for solid oral-dose medicines and predicts maintenance needs. The work led Pfizer to implement a time-series manufacturing analytics tool that its large molecule group also uses.
- Models
- Amazon SageMaker, Amazon Lookout for Equipment and Lookout for Metrics
AI commercial planning platform
Pfizer's commercial organization uses an AI-powered planning platform that helps colleagues reach healthcare providers at the right moment with the right information, according to Albert Bourla's letter in the 2026 proxy statement.
Health Answers by Pfizer
Health Answers by Pfizer is a generative AI platform that gives consumers health and wellness information; Dennis Hancock founded it before becoming CIO, and the platform has earned a Webby People's Choice Award, PM360's Product Launch of the Year recognition and Fast Company recognition in 2025 (CDO Magazine, Jul 2026).
Boltz custom foundation modelsJan 2026
Boltz is refining its Boltz-2 and BoltzGen biomolecular foundation models on Pfizer's historical data into exclusive Pfizer models for structure prediction, small-molecule affinity and biologics design, and building custom models and workflows with Pfizer discovery teams for target programs.
- Models
- Boltz-2 and BoltzGen, refined on Pfizer data
Chai Discovery platformJun 2026
Pfizer scientists are to use Chai Discovery's AI platform, including its Chai-3 model, with custom software to design therapeutic antibodies, under a license agreement announced in Jun 2026 with undisclosed terms.
- Models
- Chai-3
Vendors and partners
Amazon Web Services2021 (PACT)
Cloud and AI services: Amazon Bedrock and SageMaker behind Vox, Kendra, the Scientific Data Cloud; PACT prototyping program · AWS solutions architects and its prototyping team build prototypes with Pfizer teams under PACT, and AWS Professional Services guides successful ones toward production. AWS's page on Lidia Fonseca's re:Invent keynote (Nov 2023) says Pfizer went from about 10% to 80% cloud-based.
Anthropic
Claude 2.1 model behind Vox, through Amazon Bedrock · Reported in an undated AWS case study; Pfizer has not said which Claude models it uses today.
OpenAIBy Feb 2024
A custom version of ChatGPT generates content in Charlie · Digiday reported the custom ChatGPT in Feb 2024; Pfizer has not said whether it contracts with OpenAI directly or through Publicis Groupe.
Publicis Groupe2023
Built Charlie on its Marcel platform and maintains it · A dedicated Publicis Groupe team maintains and develops Charlie, according to Digiday (Feb 2024).
XtalPiMay 2018
AI molecular modeling for small-molecule discovery; quantum computing
PostEra
AI drug discovery collaboration · Named by Fortune in Sep 2026 as one of Pfizer's key AI partners.
BoltzJan 2026
Biomolecular foundation models refined on Pfizer data
Chai DiscoveryJun 2026
Chai-3 antibody design model, licensed
Leadership
AI, data and platform leaders
Executives
Board
AI org map
Central technology team runs the AI backbone; divisions own their AI strategy, models and spending
Pfizer's Chief Digital and Technology Officer, Lidia Fonseca, sat on the Executive Leadership Team from Jan 2019 and led enterprise AI, digital, data and technology strategy until Apr 2026, adding Berta Rodriguez-Hervas as Chief AI and Analytics Officer and AI Council co-chair in Aug 2024. Pfizer promoted Jeremy Forman to Chief AI, Data and Analytics Officer in Feb 2026; Fonseca became Senior Advisor to the CEO in May 2026, and Pfizer promoted Dennis Hancock to Chief Information Officer and Executive Vice President to lead enterprise technology, digital and AI strategy (CDO Magazine, Jul 2026). Pfizer divisions own their AI strategies and spending, and R&D embeds AI engineers in each function.
Pfizer has not disclosed how many people work on AI or data. Pfizer's AI work sits in three places: the technology organization, known as Pfizer Digital, which runs the enterprise AI backbone, added a Chief AI and Analytics Officer in Aug 2024 and promoted Jeremy Forman to Chief AI, Data and Analytics Officer in Feb 2026, with a Head of AI Center of Excellence and a Chief AI Architect being recruited to report to him (AIM Media House, Mar 2026); AI engineers that R&D is recruiting into each function, from discovery to clinical trial execution (Feb 2026); and teams in each division that own their AI strategy and spending. Pfizer also runs digital innovation teams in its pharmaceutical sciences group, which built the PACT prototypes with AWS, and in marketing, which runs Charlie.
Reporting lines
Chairman and CEO
Albert Bourla
Senior Advisor to the CEO
Lidia Fonseca
Since May 2026; Chief Digital and Technology Officer from Jan 2019 to Apr 2026
Technology (Pfizer Digital)
Dennis Hancock, CIO and EVP
Runs the enterprise AI backbone and enterprise technology, digital and AI strategy; the line to the CEO is inferred from Hancock's EVP title and listing among Pfizer's executives, not published
AI, data and analytics
Chief AI, Data and Analytics Officer since Feb 2026, with a Head of AI Center of Excellence and a Chief AI Architect being recruited under him; Berta Rodriguez-Hervas was Chief AI and Analytics Officer and AI Council co-chair from Aug 2024. Placement in Pfizer Digital follows Forman's earlier Pfizer Digital title; the reporting line is not published
U.S. Commercial
International Commercial
Sets its own AI priorities, tests tools and rolls them out across ex-U.S. markets
Pfizer's 2025 Form 10-K lists Lidia Fonseca as an executive officer and member of the Executive Leadership Team; Medtronic's Aug 2026 proxy and ManpowerGroup's Oct 2026 release say she left the Chief Digital and Technology Officer role in Apr 2026 and has advised the CEO since May 2026. Pfizer has not published Dennis Hancock's or Jeremy Forman's reporting lines, the exact date Hancock took over enterprise technology, digital and AI strategy, or whether Berta Rodriguez-Hervas remains at Pfizer.
Named people
Use cases
Pfizer has not published a count of its AI use cases; its executives describe AI in production across drug discovery, clinical development, regulatory, pharmacovigilance, manufacturing, supply planning, field sales, marketing and enabling functions. Pfizer has credited one use case with a business return: Albert Bourla said in Feb 2026 that Golden Batch delivered a very big part of the savings from Pfizer's manufacturing optimization program, which reached about $600 million by the end of 2025. At the firm level Bourla said in Jan 2026 that AI was a significant contributor to the $5.6 billion of cost Pfizer took out, without separating AI's share from simplification and pipeline prioritization.
| Use case | Area | Status | ROI |
|---|---|---|---|
| AI embedded across R&D functions Pfizer R&D embeds AI and AI engineers in discovery, medical, regulatory, safety, pharmacovigilance and clinical trial execution to measure and improve productivity, speed and cost; Alexandre de Germay said in Sep 2026 that AI lets study reports be produced a few days after the last patient visit instead of three months. | R&D | In production | |
| Virtual screening and molecular simulation Pfizer uses AI to run virtual simulations that screen molecular compounds, cutting scientific computation by as much as 90% at times compared with lab work (Fortune, Sep 2026); Pfizer began molecular modeling work with XtalPi in May 2018. | Drug discovery | In production | |
| Machine-learning molecule design Albert Bourla said Pfizer used machine learning to design Paxlovid, synthesizing 600 computer-designed molecules and finishing the preclinical phase in four months instead of the usual four years. | Drug discovery | In production | |
| Boltz custom biomolecular models Boltz is refining its open-source foundation models on Pfizer's historical data and building custom models and workflows with Pfizer discovery teams for structure prediction, small-molecule affinity and biologics design. | Drug discovery | Pilot | |
| Antibody design with Chai-3 Pfizer licensed Chai Discovery's AI platform, including the Chai-3 model, in Jun 2026 to design therapeutic antibodies against targets traditional methods have struggled to reach. | Drug discovery | Announced | |
| Document search with Vox Pfizer scientists ask Vox questions by voice or chat to find historical data across the roughly 20,000 documents one drug can generate; Pfizer estimated scientists could save up to 16,000 hours of searching a year. | Pharmaceutical sciences | Pilot | |
| Golden Batch Golden Batch is an AI use case that optimizes Pfizer's manufacturing, according to Pfizer's Q4 2025 earnings slides, which list AI as enabling phase 1 of the Manufacturing Optimization Program; Pfizer has not described how Golden Batch works. | Manufacturing | In production | CEO credited it with a very big part of ~$600M manufacturing program savings through 2025 (Feb 2026)Source |
| PCMM anomaly detection and analytics Machine learning on Amazon SageMaker detects anomalies in Pfizer's continuous oral-dose manufacturing line and predicts maintenance needs, and grew into a time-series manufacturing analytics tool also used by the large molecule group. | Manufacturing | In production | |
| Supply planning Pfizer uses AI to optimize supply planning, which Albert Bourla said contributes to the goals of Pfizer's manufacturing optimization program (Feb 2026). | Supply chain | In production | |
| Field force planning, targeting and training Pfizer uses AI to train sales representatives, plan their calls, target physicians and review the quality of rep interactions, and an AI planning platform helps colleagues reach healthcare providers with the right information at the right moment. | Commercial | In production | |
| Charlie marketing content Charlie drafts digital media, emails and sales presentations, routes content through medical, legal and regulatory review by risk level, and checks answers against approved Pfizer content. | Marketing | In production | |
| Promotional material review across markets Pfizer uses AI to reassess promotional pieces against each country's regulatory requirements, so markets no longer redo every review one by one (Feb 2026). | International commercial | In production | |
| Health Answers by Pfizer Health Answers by Pfizer uses generative AI to answer consumers' health and wellness questions. | Patient engagement | In production | |
| Automation in finance, HR and legal Pfizer embeds AI that its large technology vendors add to their platforms and uses AI to automate routine transactions across hundreds of markets in finance, HR, legal and other enabling functions (Feb 2026). | Enabling functions | In production |
Adoption
Pfizer has used AI for more than a decade, according to Fortune. The PACT program with AWS began in 2021, Charlie reached hundreds of central marketers and thousands of people across Pfizer brands by Feb 2024, and Pfizer appointed a Chief AI and Analytics Officer in Aug 2024. Pfizer says 98% of eligible employees have taken the first course of an AI certification program tailored to every role and function, which Fortune reported in Sep 2026 as 98% of the workforce completing AI certification, and Albert Bourla said in May 2026 that Pfizer pairs frontier AI tools tailored to each function and role with continuously updated training. Pfizer has not published how many employees use its AI tools daily or weekly.
By the numbers
Rollout, first pilot to today
May 2018
Pfizer partnered with XtalPi to develop AI-powered molecular modeling software for small-molecule drug discovery.
Jan 2019
Lidia Fonseca became Pfizer's Chief Digital and Technology Officer and joined the Executive Leadership Team.
2021
Pfizer's Pharmaceutical Sciences Small Molecule group and AWS launched PACT, which later gave scientists Claude on Amazon Bedrock through Vox.
Nov 2023
Lidia Fonseca presented Pfizer's AI and cloud work at AWS re:Invent, including Vox, a generative AI tool built on Amazon SageMaker and Amazon Bedrock models.
Feb 2024
Pfizer was rolling out Charlie, a generative AI marketing platform built with Publicis Groupe, to hundreds of central marketers and thousands across its brands.
Aug 2024
Pfizer appointed Berta Rodriguez-Hervas as Chief AI and Analytics Officer and co-chair of its AI Council.
Apr 2025
Pfizer added about $1.2 billion of targeted savings by the end of 2027, driven in large part by digital enablement including automation and AI.
Feb 2026
Albert Bourla made scaling AI one of Pfizer's four 2026 priorities and announced an expansion to more than 1,200 GPUs over two years.
Feb 2026
Pfizer promoted Jeremy Forman to Chief AI, Data and Analytics Officer to integrate AI and data across the enterprise.
Jul 2026
Pfizer promoted Dennis Hancock to Chief Information Officer and Executive Vice President to lead enterprise technology, digital and AI strategy, after Lidia Fonseca left the Chief Digital and Technology Officer role in Apr 2026.
Sep 2026
Fortune reported that 98% of Pfizer's workforce had completed an AI certification program; Pfizer's own wording is that 98% of eligible colleagues have taken the first course.
Economics & controls
Spend and ROI
Technology and AI spend
Pfizer does not disclose a technology budget or what AI costs. Pfizer expects to invest about $11 billion in R&D in 2026 and is expanding to more than 1,200 GPUs over two years, largely for AI in R&D (Feb 2026 earnings call). Pfizer's AI-linked savings carry one-time costs that include digital enablement: about $1.6 billion for the Apr 2025 savings tranche and about $2.0 billion for the Aug 2026 tranche, alongside implementation and severance.
Reported ROI
Pfizer has not published a dollar return for AI on its own. Albert Bourla said on Jan 12, 2026 that AI was a significant contributor to the $5.6 billion of cost Pfizer took out, with more in manufacturing, and on Feb 3, 2026 that AI was the main lever, with simplification also contributing, that let Pfizer cut costs without hurting revenue. Pfizer's 2025 Form 10-K puts the Realigning Our Cost Base program at $5.1 billion of net savings through 2025, plus about $500 million of R&D savings from pipeline focus and optimization including digital capabilities, which Chris Boshoff tied to prioritization; Pfizer expects $6.7 billion of program savings through 2029 after the Aug 2026 expansion. Bourla credited the Golden Batch use case with a very big part of the manufacturing program's savings, about $600 million by the end of 2025.
Productivity markers
Aamir Malik said in Feb 2026 that AI has raised Pfizer's marketing return on investment by targeting spend more precisely and lets field forces spend more time with physicians, and Pfizer said in Aug 2026 that scaling AI supported its field force in driving access and uptake for new launches. Alexandre de Germay said in Sep 2026 that the productivity of Pfizer's international sales organization tripled in three years, crediting a more focused deployment of resources and, for a lot of the gain, advanced analytics and AI. Pfizer told Fortune in Sep 2026 that AI virtual screening cuts scientific computation by as much as 90% at times versus lab work, and an undated AWS case study says Pfizer estimated Vox could save scientists up to 16,000 hours of searching a year.
Headcount
Pfizer employed about 75,000 people at Dec 31, 2025. Pfizer has not said how many roles its AI-linked savings remove, but the one-time costs of the Apr 2025 and Aug 2026 savings tranches are mainly severance, digital enablement and implementation, and Albert Bourla said in Feb 2026 that Pfizer improved productivity rather than simply cutting cost.
Governance and risk
Board oversight
Pfizer's board counts cybersecurity and AI among the enterprise risks it considers (2026 proxy), and the Audit Committee oversees cybersecurity risk management (2025 Form 10-K). Pfizer's 2026 proxy reports that investors asked whether the board is recruiting directors with AI expertise; the board answered that some directors bring technology experience, including AI, and Scott Gottlieb's proxy biography cites his seats on the boards of Tempus AI and Xaira Therapeutics.
AI Council and responsible use
Pfizer runs an AI Council, which Chief AI and Analytics Officer Berta Rodriguez-Hervas joined as co-chair in Aug 2024; Pfizer has not said who co-chairs the AI Council since Jeremy Forman's Feb 2026 promotion. Pfizer's business conduct policies cover the responsible use of AI along with privacy and the protection of confidential information (2026 proxy).
Review of generated content
Pfizer's Charlie platform labels marketing content red, yellow or green so medical reviewers can focus on new claims, validates answers against previously published and approved Pfizer content, and keeps a human review step for outputs, according to Digiday (Feb 2024).
Disclosed risks
Pfizer's 2025 Form 10-K warns that generative AI output can be false, inconsistent or hard to reproduce, that models can degrade through data drift or vendor updates, that training data may lack the necessary rights, that AI use could leak confidential information, and that reliance on a small number of AI models or providers is a risk. Pfizer's 2026 quarterly filings add the risk that expected savings from AI, automation and digital enablement may not arrive on time or in full, and the 10-K names the EU AI Act among the rules that affect Pfizer.
Data and IP in partnerships
Pfizer keeps full ownership of all compounds discovered or developed with Boltz's models, and the models Boltz refines on Pfizer's historical data are exclusive to Pfizer (Jan 2026). Pfizer's chief information security officer works with the Chief Digital Officer, CFO and Chief Legal Officer on cyber risk, which the 10-K says increasingly includes adversarial AI techniques such as automated phishing.
Recent signals
Oct 28, 2026
ManpowerGroup elected Lidia Fonseca to its board from Nov 1, 2026, describing her as Pfizer's Chief Digital and Technology Officer from Jan 2019 to Apr 2026, now Senior Advisor to the CEO, who built Pfizer's enterprise AI program.
Sep 29, 2026
Fortune ranked Pfizer 48th on its AIQ 75 list, reporting that 98% of Pfizer's workforce had completed an AI certification program, and CIO Dennis Hancock set a goal of using AI from DNA to patient.
Sep 22, 2026
Alexandre de Germay told a JPMorgan conference that Pfizer's divisions set their own AI priorities, that advanced analytics and AI drove much of a tripling in international sales force productivity, and that AI cut study report times from three months to days.
Aug 17, 2026
Medtronic's proxy statement disclosed that Lidia Fonseca became Senior Advisor to Pfizer's CEO in May 2026 after serving as Chief Digital and Technology Officer.
Aug 4, 2026
Albert Bourla said AI is already cutting cost and raising yields in manufacturing and set a goal of an AI-native R&D organization, as Pfizer added $1.0 billion of net savings for 2027 to 2029 from technology and simplification.
Jul 6, 2026
CDO Magazine reported that Pfizer promoted Dennis Hancock, a Pfizer employee since 1995 who founded Health Answers by Pfizer, to Chief Information Officer and Executive Vice President over enterprise technology, digital and AI strategy.
Jun 4, 2026
Pfizer licensed Chai Discovery's AI platform, including the Chai-3 model, to design therapeutic antibodies.
May 5, 2026
Albert Bourla said Pfizer pairs frontier AI tools tailored to each role with continuous training and that the coming years are for the AI transformation of Pfizer rather than a large merger.
Apr 10, 2026
Pfizer moved its search engine and AI discoverability work in-house, building the team in about 60 days.
Mar 12, 2026
Pfizer's proxy statement listed AI among the board's enterprise risk topics and reported investor questions about the board's AI expertise.
Feb 3, 2026
Albert Bourla made scaling AI one of Pfizer's four 2026 priorities, announced an expansion to more than 1,200 GPUs and called AI the main lever behind Pfizer's cost cuts.
Feb 3, 2026
CDO Magazine reported that Pfizer promoted Jeremy Forman, its Vice President of Global R&D AI, Data and Analytics since Mar 2024, to Chief AI, Data and Analytics Officer.
Jan 27, 2026
Albert Bourla told Fortune that machine learning cut Paxlovid's preclinical phase from four years to four months and that AI winners will be those that transform their organizations.
Jan 12, 2026
Albert Bourla told the J.P. Morgan Healthcare Conference that AI was a significant contributor to the $5.6 billion of cost Pfizer took out and that Pfizer is ready to scale AI across the organization.
Jan 8, 2026
Pfizer and Boltz announced a collaboration to build exclusive biomolecular foundation models refined on Pfizer's historical data.
Quick answers
- How does Pfizer deploy AI?
- Pfizer deploys AI through an enterprise backbone run by its technology team, while each division owns its AI strategy, models and spending. Named tools include Vox, which gave scientists Anthropic's Claude on Amazon Bedrock, and Charlie for marketing content; Boltz and Chai Discovery supply drug discovery models. Pfizer made scaling AI a 2026 priority and says 98% of eligible employees took its first AI course. Albert Bourla calls AI a significant contributor to $5.6 billion of cost cuts, without separating its share.
- What does Pfizer use AI for?
- Pfizer has not published a count of its AI use cases; its executives describe AI in production across drug discovery, clinical development, regulatory, pharmacovigilance, manufacturing, supply planning, field sales, marketing and enabling functions. Pfizer has credited one use case with a business return: Albert Bourla said in Feb 2026 that Golden Batch delivered a very big part of the savings from Pfizer's manufacturing optimization program, which reached about $600 million by the end of 2025. At the firm level Bourla said in Jan 2026 that AI was a significant contributor to the $5.6 billion of cost Pfizer took out, without separating AI's share from simplification and pipeline prioritization.
- Who leads AI at Pfizer?
- AI at Pfizer is led by Lidia Fonseca (Senior Advisor to the CEO; Chief Digital and Technology Officer, Jan 2019 to Apr 2026); Dennis Hancock (Chief Information Officer and Executive Vice President); Jeremy Forman (Chief AI, Data and Analytics Officer). Ownership of AI on the org chart: CIO and EVP Dennis Hancock; Chief AI, Data and Analytics Officer Jeremy Forman (Feb 2026).
- What AI platform does Pfizer use?
- Pfizer's technology team builds and manages an enterprise AI backbone while each division owns its AI strategy, model use and investment (Fortune, Sep 2026); named tools include Vox for scientists and Charlie for marketing content.
- Which AI models does Pfizer use?
- Pfizer's Vox gave scientists Anthropic's Claude 2.1 through Amazon Bedrock (undated AWS case study), Charlie generated marketing content with a custom version of ChatGPT built with Publicis Groupe (Feb 2024), and Boltz and Chai Discovery supply drug discovery models (2026).
- How many Pfizer employees use AI?
- Pfizer says 98% of eligible employees have taken the first course of its AI certification program, which Fortune reported in Sep 2026 as 98% of the workforce; Pfizer employed about 75,000 people at the end of 2025 and has not published how many use its AI tools each week.
- How far has AI spread at Pfizer?
- Pfizer sits at Scaling: AI runs in production across drug discovery, clinical development, manufacturing, supply planning, field sales, marketing and enabling functions, 98% of eligible employees have taken the first course of Pfizer's AI certification program, scaling AI is one of Pfizer's four 2026 priorities, and Albert Bourla reports AI results on earnings calls. CIO Dennis Hancock owns enterprise AI strategy, and Jeremy Forman has been Chief AI, Data and Analytics Officer since Feb 2026. Pfizer falls short of Embedded on two tests: Pfizer has published no weekly usage figure or count of AI use cases, and has not separated AI's share of its cost savings from simplification.
Open questions
- Does CIO and EVP Dennis Hancock report directly to Albert Bourla and sit on the Executive Leadership Team, when did he take over the technology, digital and AI remit Lidia Fonseca held until Apr 2026, and does Chief AI, Data and Analytics Officer Jeremy Forman report to him?
- Has Berta Rodriguez-Hervas, Chief AI and Analytics Officer from Aug 2024, left Pfizer, and who co-chairs the AI Council now?
- How many Pfizer employees use AI tools each week, as distinct from the 98% of eligible employees who took the first AI course, and which tools do they use?
- What share of the $5.6 billion of cost Pfizer took out through 2025, including about $500 million of R&D savings, came from AI rather than simplification, pipeline prioritization and job cuts?
- How much of the tripling of international sales force productivity that Alexandre de Germay described in Sep 2026 does Pfizer credit to AI rather than to a more focused deployment of resources?
- Can Pfizer's own value figures for AI be confirmed? A third-party summary of a Lidia Fonseca interview attributes to her more than $1 billion of incremental value from AI programs, and a Pfizer biography of Fonseca, seen only in a search summary, said AI was expected to deliver $4 billion; neither appears in Pfizer's filings or earnings calls.
- Where do Pfizer's planned 1,200-plus GPUs run: in Pfizer's own data centers, on AWS or with another cloud provider?
- Which models power Pfizer's enterprise AI backbone today, beyond the Claude 2.1 in Vox and the custom ChatGPT in Charlie reported in 2024, and is Charlie still in use?
- What business return do Pfizer's deployed tools with no published figure deliver, such as Vox, Charlie, field force planning and cross-market promotional review?
- What does the Golden Batch use case do, and how much of the roughly $600 million of 2025 manufacturing savings does Pfizer attribute to it?
- How many AI engineers has Pfizer R&D hired into its functions, and how many AI and data specialists does Pfizer employ overall?
- What do the Boltz and Chai Discovery agreements cost Pfizer, and have they produced development candidates?
Sources
Pfizer filings and investor materials
- Pfizer 2025 Form 10-K (filed Feb 26, 2026)
- Pfizer 2026 proxy statement (Mar 12, 2026)
- Pfizer Form 10-Q, first quarter 2026 (May 2026)
- Pfizer Form 10-Q, second quarter 2026 (Aug 2026)
- Pfizer second-quarter 2026 earnings release (Aug 4, 2026)
- Pfizer Form 8-K on added cost savings (Apr 29, 2025)
- Q4 2025 earnings call transcript (Feb 3, 2026)
- Q4 2025 earnings presentation (Feb 3, 2026)
- J.P. Morgan Healthcare Conference transcript (Jan 12, 2026)
- JPMorgan U.S. All Stars Conference transcript, Alexandre de Germay (Sep 22, 2026)
- Pfizer: Pfizer Learns to Speak AI with Fluency Program
- Q1 2026 earnings call transcript (May 5, 2026)
- Q2 2026 earnings call transcript (Aug 4, 2026)
- Form 8-K, 2026 annual meeting voting results (Apr 2026)
- Pfizer executive biography: Dennis Hancock
Other company filings
Partners
News
- Fortune: From Pfizer to UPS, the newest members of the AIQ 75 (Sep 29, 2026)
- Fortune: Albert Bourla on Titans and Disruptors of Industry (Jan 27, 2026)
- BioPharma Dive: Pfizer expands cost cuts again (Aug 4, 2026)
- BioPharma Dive: Pfizer cuts an AI deal with Chai Discovery (Jun 4, 2026)
- AIM Media House: Pfizer adds AI executive layer as tech investments mount (Mar 5, 2026)
- CDO Magazine: Pfizer promotes Jeremy Forman to Chief AI, Data and Analytics Officer (Feb 3, 2026)
- MarketScreener: Berta Rodriguez-Hervas insider profile
- Digiday: Pfizer brings AI search work in-house (Apr 10, 2026)
- Digiday: With Charlie, Pfizer builds a generative AI platform for pharma marketing (Feb 22, 2024)
- CDO Magazine: Pfizer promotes Dennis Hancock to CIO and EVP (Jul 6, 2026)
- CIO Dive: Pfizer appoints AI chief (Aug 13, 2024)
- CDO Magazine: Pfizer appoints Berta Rodriguez-Hervas (Aug 19, 2024)
- pharmaphorum: Pfizer grows digital team with chief AI officer (Aug 18, 2024)
- pharmaphorum: Pfizer partners with XtalPi on AI drug discovery (May 13, 2018)
Data confidence
- Confirmed
- Stated in a primary or reputable public source.
- Estimated
- Derived or approximated from public reporting.
- Unconfirmed
- Reported, but not yet corroborated.
Pfizer profile · Enterprise AI diffusion report by Imagine · facts checked against their sources on Nov 1, 2026